A brief introduction to cell-penetrating peptides
نویسندگان
چکیده
منابع مشابه
Cell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
متن کاملIdentification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides.
Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...
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the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...
متن کاملArginine-rich cell-penetrating peptides.
Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
متن کاملMechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides.
Pancreatic-type ribonucleases can exert toxic activity by catalyzing the degradation of cellular RNA. Their ability to enter cells is essential for their cytotoxicity. Here, we determine the mechanism by which bovine pancreatic ribonuclease (RNase A) enters human cells. Inhibiting clathrin-dependent endocytosis with dynasore or chlorpromazine decreases RNase A-uptake by ~70%. Limited colocaliza...
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ژورنال
عنوان ژورنال: Journal of Molecular Recognition
سال: 2003
ISSN: 0952-3499,1099-1352
DOI: 10.1002/jmr.630